Some determinants of camptothecin responsiveness in leukemia L1210 cells.
نویسنده
چکیده
The antineoplastic alkaloid camptothecin inhibits nucleic acid synthesis in leukemia LI 210 cells; this inhibition is initially reversible, but becomes irreversible when exposure to the drug is prolonged. A drug-resistant subline, L1210/CN, can overcome camptothecin-induced inhibition of nucleic acid biosynthesis before this becomes irreversible. Unlike actinomycin D-resistant cell lines, L1210/CN was not characterized by a drug permeability barrier nor by altered levels of cell surface glycoprotein.
منابع مشابه
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ورودعنوان ژورنال:
- Cancer research
دوره 31 12 شماره
صفحات -
تاریخ انتشار 1971